The ensemble of the Liškiava Church and the Dominican Monastery is an architectural monument of the 17th-18th centuries. In 1694, Vladislovas Jurgis Kosyla bequeathed Liškiava to the Dominican monks of the Province of Lithuania by a foundation letter. After long legal battles with the wives of V. J. Kosyla, the monks built a church and a monastery on the steep bank of the Nemunas River (completed by 1741), with outbuildings, a churchyard, a cemetery, and a garden adjoining it. All the buildings were surrounded by a high brick fence.
After the Third Partition of Lithuania-Poland, Lviv was given to Prussia and the abandoned buildings began to crumble. Around 1830, the Liškiava monastery was used as a penitentiary for demerit priests. Later, the buildings changed hands. In 1920, when Liškiava became the centre of the municipality, the monastery's rooms housed a post office, a post office, and a grocery shop. In 1939, representatives of the Alytus County Municipality and the Vilkaviskis Curia signed an agreement to establish a tourist centre in the monastery buildings. However, the Liškiava tourist camp soon turned into a refugee camp for refugees from Poland.
In 1941, the monastery building was taken over by the Alytus Municipal Economy Department. In 1946-1976, an eight-year school was opened here. In 1977, the monastery buildings were given to the "Lelija" association: the former central palace of the monastery was to be used as a pioneer camp - a holiday home. In 1991 this project had to be modified, as part of the monastery building was given to the rectory.
In 1990-1997 the church was restored and a museum with mummified remains was built in its crypt.