She studied filmmaking at the Lithuanian Academy of Music and Theatre from 2010 to 2014. During this period, she directed five short films, three of which were selected for the Vilnius International Film Festival (Kino pavasaris).

In 2016, Marija Kavtaradze co-wrote the feature film The Saint, directed by Andrius Blaževičius and produced by Marija Razgutė (M-Films). The film premiered at the Busan International Film Festival and the Warsaw International Film Festival in 2016.

In collaboration with director Andrius Blaževičius and Teklė Kavtaradzė, she co-wrote the 2021 feature film Runner, directed by Andrius Blaževičius and produced by Marija Razgutė. The film had its premiere at the Karlovy Vary International Film Festival in 2021.

She wrote and directed her first feature film, Summer Survivors, in 2018, also produced by Marija Razgutė (M-Films). The film had its world premiere at the Toronto International Film Festival in 2018 and went on to be selected for numerous festivals, winning three national film awards.

In 2023, she wrote and directed Slow, her third collaboration with producer Marija Razgutė (M-Films). The film premiered at the Sundance Film Festival, where Marija Kavtaradze won the Best Director award.

She is currently developing and co-writing the debut feature film of Vytautas Katkus, The Visitor, produced by M-Films.